Friday around 10 p.m., charter buses packed with residents from the Grand Strand and Pee Dee will leave Florence to participate in the "Justice for Trayvon" rally in Sanford, Florida on Saturday.
Last month, George Zimmerman, 28, shot and killed Trayvon Martin, 17, while Martin was on his way home.
The case has gained national attention because many believe Zimmerman should have been charged for Martin's death, and at this time, police have not issued any charges.
"I don't think this is really a case about race. It's about justice," said Myrtle Beach NAACP President Mickey James. "At first, it may have been about race, but I think it's about justice and equality now."
James is among the hundreds of South Carolinians expected to join the rally.
The South Carolina NAACP is organizing buses to bring anyone, NAACP member or not, to the rally.
"The Civil Rights movement was not built on the backs of African Americans alone," said NAACP member Bennie Swans. "It was a coalition of blacks, whites, jew and gentiles all working together to change. I think what is reflective with this loss of life is that the same thing is coming to surface, people working together for justice."
Those interested can purchase tickets online for $57.37.
Along with the buses leaving from Florence, buses organized by the South Carolina NAACP chapter will head to Florida from Columbia, North Charleston and Orangeburg.
The Florence buses will leave Magnolia Mall at 2701 David H. McLeod Boulevard on Friday.
James said members from the Myrtle Beach area plan to car pool to Florence, and anyone interested in joining can email the local chapter at mbnaacp@yahoo.com.
"I'm going to be a voice for him or anybody else who has been mistreated whether they are black or white, because a young man is gone now. All we can do now is try to make it better for other folks regardless of who they are," said James.
Trayvon's mother and father are expected to attend the rally. It's estimated ten of thousands will travel to Sanford this weekend.
"I think the main thing is, is to show continuity and strength among numbers," said James.
Once the rally is over at 3 p.m. Saturday, the buses will travel back to South Carolina.