West Florence Fire crews and South Carolina Highway Patrol responded to a single vehicle wreck on the connector between I-95 South and I-20 West.
An 18-wheeler ran off the highway and went in to the woods, according to Captain Fox with the West Florence Fire Department.
There are no injuries as a result of the crash, Fox said.
Firefighters had to contain a fuel leak from the tractor.
DHEC has been notified of the spill.
The wreck has been cleared and traffic should be moving smoothly again.