48 people who work at McLeod's Loris Hospital and Seacoast Medical Center lost their jobs.
A spokesperson for the hospital says the layoffs are partly due to cuts in federal and state funding of more than $2.5 million.
The hospital also says a drop in patients because of the economic downturn has made it more difficult for the facilities to pay down a loan from the federal government.
Last month, the two hospitals became affiliated with McLeod Health.
