The movie, "The Bay," formerly called "Isopod," will be shooting Monday in Georgetown, and it will impact traffic on the Highway 17 bridges going into the city.
The Georgetown County Sheriff's Office says deputies will be helping film crews in the area of the Black River/Waccamaw Bridges (U.S. 17) between the hours of 3:00 p.m. and 9:00 p.m.
Georgetown County Sheriff's Office personnel will be stopping north and south bound traffic for brief periods during this time.
The film's producer has said traffic should not be interrupted for more than five minutes for each take and has estimated they'll shoot between 4 and 6 takes.
The movie is a fictional catastrophe, and although the movie's production crew has been in Georgetown for a few weeks, they haven't said much about the movie's plot.
The independent production will be led by Barry Levinson, the Oscar winning director of "Rain Man."
City officials say location scouts chose Georgetown because they wanted a coastal community, and they liked the town's oak-draped streets and waterfront scenery.
There's no word yet on who might star in the film.
Georgetown has been the scene for several previous movies, including The Patriot and The Notebook.